Table 5.
Drug (generic) | Dosage | Mean Weight Loss above Lifestyle | Common Side Effects | Contraindications | Special Populations |
---|---|---|---|---|---|
Phentermine/Topiramate | 7.5/46 mg daily | 6.6 kg, 1 year | Insomnia, dry mouth, nausea | Pregnancy, multiple drug interactions | Young, no CVD risk factors |
Liraglutide | 3.0 mg daily | 5.8 kg, 1 year | Nausea, vomiting, pancreatitis | Medullary thyroid cancer, MEN-2 | Type 2 diabetes |
Lorcaserin | 10 mg bid | 3.6 kg, 1 year | Headache, nausea | Pregnancy, multiple drug interactions | CVD risk factors |
Naltrexone/Bupropion | 32/360 mg qid | 4.8 kg, 1 year | Nausea, constipation | Seizure, eating disorder, drug or ETOH withdrawal | Addiction disorders |
Orlistat (Rx and OTC) | 60/120 mg tid | 2.9–3.4 kg, 1 year | Steatorrhea, flatulence, fecal discharge | Cyclosporine, malabsorption, pregnancy, certain meds | Available over-the-counter |
Modified from reference 102