Table 4. The interactive influence of metformin and opioids on gut microbiota in the subgroup with diabetes.
| LogFC | LogCPM | p value | q value | |
|---|---|---|---|---|
| Bifidobacterium | ||||
| Interaction of Op and MF | 5.5x10-6 | 1.1x10-4 | ||
| Op-/MF+ vs Op-/MF- | 3.17 | 11.95 | 3.4x10-3 | 0.03 |
| Op+/MF+ vs Op+/MF- | -3.67 | 14.82 | 1.2x10-3 | 0.01 |
| Op+/MF- vs Op-/MF- | 6.74 | 14.59 | 1.2x10-9 | 2.2x10-8 |
| Op+/MF+ vs Op-/MF+ | 0.53 | 12.40 | 0.51 | 0.88 |
| Prevotella | ||||
| Interaction of Op and MF | 4.3x10-3 | 0.04 | ||
| Op-/MF+ vs Op-/MF- | -1.03 | 14.04 | 0.51 | 0.88 |
| Op+/MF+ vs Op+/MF- | 10.43 | 14.07 | 8.4x10-4 | 0.01 |
| Op+/MF- vs Op-/MF- | -9.94 | 13.64 | 4.4x10-3 | 0.04 |
| Op+/MF+ vs Op-/MF+ | 0.31 | 14.56 | 0.73 | 0.90 |
| Species | ||||
| Prevotella unidentified | ||||
| Interaction of Op and MF | 8.9x10-3 | 0.16 | ||
| Op-/MF+ vs Op-/MF- | -0.65 | 14.42 | 0.63 | 0.92 |
| Op+/MF+ vs Op+/MF- | 10.31 | 14.27 | 1.5x10-3 | 0.03 |
| Op+/MF- vs Op-/MF- | -9.85 | 13.85 | 0.01 | 0.09 |
| Op+/MF+ vs Op-/MF+ | 1.13 | 14.62 | 0.46 | 0.85 |
| Bacteroides caccae | ||||
| Interaction of Op and MF | 0.03 | 0.19 | ||
| Op-/MF+ vs Op-/MF- | -3.69 | 16.22 | 6.12x10-5 | 1.4x10-3 |
| Op+/MF+ vs Op+/MF- | -0.09 | 13.22 | 0.92 | 0.99 |
| Op+/MF- vs Op-/MF- | -6.09 | 18.24 | 2.8x10-3 | 0.06 |
| Op+/MF+ vs Op-/MF+ | -0.83 | 13.86 | 0.39 | 0.85 |
Data are taxon relative sequence abundance. The differential subgroup analysis was done using edgeR, the false discovery rate (FDR) adjusted p values (q values) were calculated using the Benjamini-Hochberg FDR correction. Abbreviations: CPM = count per million, FC = fold change, MF = metformin use, Op = opioid use, q = FDR-adjusted p value.