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. 2018 Mar 29;13(3):e0193871. doi: 10.1371/journal.pone.0193871

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© 2018 Tamez-Peña et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 4 — (A) A heat map representation of the features associated to risk from PAM50 ROR. The figure shows the features selected by LASSO (vertical axis) and their univariate Spearman coefficient and rank along samples (horizontal axis) ordered by the PAM50 ROR score. The top of the figure includes common clinical indicators. The image data was scaled to z-score to nightlight differences. Orange dots at the right represent features also present in the OncotypeDX model. (B) Comparison of the estimated PAM50 recurrence score with that of the score predicted by the image model in (A). Each dot represents a sample. Colors represent subtypes and filled or open circles represent younger or older patients.