Table 1. Description of the collagen degradation and formation assays used in this study.

Biomarker	Specification	Process	Surrogate measure
C1M[14]	Neo-epitope of MMP-2,9,13 mediated degradation of type I collagen	Type I collagen degradation	Chronic inflammation
PINP[13]	Internal epitope in the N-terminal pro-peptide of type I collagen	Type I collagen formation	Primarily bone synthesis
C3M[16]	Neo-epitope of MMP-9 mediated degradation of type III collagen	Type III collagen degradation	Chronic inflammation
Pro-C3[15]	Released N-terminal pro-peptide of type III collagen	Type III collagen formation	Fibrosis
C4M[18]	Neo-epitope of MMP-2,9,12 mediated degradation of type IV collagen alpha 1	Type IV collagen degradation	Chronic inflammation
P4NP7S[17]	Internal epitope in the 7S domain of type IV collagen	Type IV collagen formation	Fibrosis