Table 3. Sex-specific changes in collagen remodeling.
| PINP | C1M | |||||||
| Age group | Median (men) | Median (women) | Significant | P-value | Median (men) | Median (women) | Significant | P-value |
| 20–24 | 91.8 | 61.2 | Yes | 0.02 | 23.2 | 28.2 | No | 0.18 |
| 25–29 | 80.1 | 53.2 | Yes | 0.0004 | 23.0 | 25.5 | No | 0.05 |
| 30–34 | 72.9 | 50.7 | Yes | 0.001 | 23.0 | 25.2 | No | 0.84 |
| 35–39 | 62.5 | 35.8 | Yes | 0.0004 | 24.6 | 29.4 | No | 0.11 |
| 40–44 | 56.3 | 37.0 | Yes | 0.001 | 25.8 | 20.9 | No | 0.25 |
| 45–49 | 50.3 | 38.4 | No | 0.18 | 22.0 | 24.9 | No | 0.38 |
| 50–54 | 46.7 | 55.0 | No | 0.34 | 22.8 | 26.0 | No | 0.82 |
| 55–59 | 44.4 | 56.2 | Yes | 0.01 | 25.6 | 24.4 | No | 0.85 |
| 60–64 | 33.2 | 64.7 | Yes | <0.0001 | 25.2 | 26.1 | No | 0.66 |
| 65–69 | 36.1 | 59.9 | Yes | 0.001 | 26.5 | 26.0 | No | 0.62 |
| 70–74 | 37.3 | 48.9 | No | 0.19 | 27.0 | 32.4 | No | 0.27 |
| 75–79 | 44.6 | 57.4 | No | 0.10 | 22.5 | 26.3 | No | 0.67 |
| 80+ | 45.1 | 62.5 | Yes | 0.02 | 26.2 | 24.4 | No | 0.90 |
| PRO-C3 | C3M | |||||||
| Age group | Median (men) | Median (women) | Significant | P-value | Median (men) | Median (women) | Significant | P-value |
| 20–24 | 8.9 | 9.1 | No | 0.80 | 9.9 | 11.8 | No | 0.07 |
| 25–29 | 8.3 | 8.6 | No | 0.66 | 9.2 | 10.8 | No | 0.21 |
| 30–34 | 7.8 | 8.9 | No | 0.85 | 10.1 | 9.7 | No | 0.68 |
| 35–39 | 8.3 | 8.0 | No | 0.25 | 9.4 | 10.1 | No | 0.30 |
| 40–44 | 7.6 | 8.0 | No | 0.87 | 8.3 | 9.1 | No | 0.33 |
| 45–49 | 7.0 | 6.8 | No | 0.94 | 9.4 | 9.1 | No | 0.78 |
| 50–54 | 7.2 | 7.4 | No | 0.70 | 9.6 | 11.2 | No | 0.24 |
| 55–59 | 8.2 | 6.8 | Yes | 0.03 | 9.6 | 11.9 | Yes | 0.02 |
| 60–64 | 8.7 | 7.9 | No | 0.38 | 9.9 | 9.4 | No | 0.49 |
| 65–69 | 7.3 | 7.2 | No | 0.31 | 9.0 | 9.7 | No | 0.20 |
| 70–74 | 8.9 | 7.2 | Yes | 0.04 | 9.7 | 10.1 | No | 0.25 |
| 75–79 | 9.5 | 7.6 | Yes | 0.01 | 9.3 | 9.1 | No | 0.64 |
| 80+ | 8.9 | 9.7 | No | 0.29 | 10.5 | 9.7 | No | 0.34 |
| P4NP7S | C4M | |||||||
| Age group | Median (men) | Median (women) | Significant | P-value | Median (men) | Median (women) | Significant | P-value |
| 20–24 | 199.5 | 245.2 | No | 0.20 | 15.9 | 18.4 | Yes | 0.04 |
| 25–29 | 185.3 | 210.9 | No | 0.49 | 15.5 | 16.8 | No | 0.56 |
| 30–34 | 224.9 | 205.6 | No | 0.52 | 17.4 | 17.6 | No | 0.89 |
| 35–39 | 182.3 | 200.8 | No | 0.27 | 16.1 | 19.1 | No | 0.50 |
| 40–44 | 190.6 | 193.3 | No | 0.82 | 17.6 | 18.9 | No | 0.70 |
| 45–49 | 202.5 | 194.2 | No | 0.72 | 18.3 | 17.5 | No | 0.36 |
| 50–54 | 212.3 | 206.8 | No | 0.77 | 19.6 | 20.8 | No | 0.58 |
| 55–59 | 196.7 | 230.3 | Yes | 0.02 | 17.4 | 22.6 | Yes | 0.001 |
| 60–64 | 200.3 | 225.2 | No | 0.88 | 19.5 | 19.9 | No | 1.00 |
| 65–69 | 190.7 | 196.9 | No | 0.31 | 19.0 | 19.5 | No | 0.25 |
| 70–74 | 199.5 | 245.2 | No | 0.20 | 15.9 | 18.4 | Yes | 0.04 |
| 75–79 | 185.3 | 210.9 | No | 0.49 | 15.5 | 16.8 | No | 0.56 |
| 80+ | 224.9 | 205.6 | No | 0.52 | 17.4 | 17.6 | No | 0.89 |
The level of the individual biomarkers between men and women in the five-year age groups was compared using the Mann-Whitney test. P-values are indicated and represent significant difference (p≤0.05) between men and women.