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. 2018 Mar 29;13(3):e0193946. doi: 10.1371/journal.pone.0193946

Table 3. Conspicuity scores.

T1w T2w ceT1w SWI FLAIR DWI
Lesions at first diagnosis MRI
n of 720 699 706 712 496 673 510
mean CS 1.77 1.82 2.91 1.94 2.32 1.42
±SD 1.14 1.17 0.30 1.22 1.05 1.27
n(CS 0) 124 (17.7%) 143 (20.3%) 0 (0%) 104 (21.0%) 72 (10.7%) 191 (37.5%)
n(CS 1) 179 (25.6%) 132 (18.7%) 2
(0.3%)
71 (14.3%) 83 (12.3%) 72 (14.1%)
n(CS 2) 131 (18.7%) 143 (20.3%) 60 (8.4%) 72 (14.5%) 75 (11.1%) 91 (17.8%)
n(CS 3) 265 (37.9%) 288 (40.8%) 650 (91.3%) 249 (50.2%) 443 (65.8%) 156 (30.6%)
Lesions at pre-diagnosis MRI
n of 33 33 33 33 23 32 24
mean CS 0.48 0.18 1.82 0.39 0.56 0.17
±SD 0.83 0.64 0.88 0.94 1.01 0.64
n(CS 0) 22 (66.7%) 30 (90.9%) 0 (0%) 19 (82.6%) 22 (68.8%) 22 (91.7%)
n(CS 1) 8 (24.2%) 1 (3.0%) 16 (48.5%) 1 (4.3%) 6 (18.8%) 1 (4.2%)
n(CS 2) 1 (3.0%) 1 (3.0%) 7 (21.2%) 1 (4.3%) 0 (0%) 0 (0%)
n(CS 3) 2 (6.1%) 1 (3.0%) 10 (30.3%) 2 (8.7%) 4 (12.5%) 1 (4.2%)
Lesions ≤ 5 mm diameter at first diagnosis MRI
n 385 390 391 270 377 293
mean CS 1.33 1.2 2.72 1.46 1.77 0.83
±SD 1.15 1.11 0.56 1.29 1.22 1.1
Leptomeningeal lesions
n of 720 77 79 76 70 77 63
mean CS 1.84 1.29 2.82 1.33 2.17 0.87
±SD 1.12 1.15 0.48 1.34 1.12 1.08
Pachymeningeal lesions
n of 720 18 19 19 17 19 17
mean CS 2.06 2.11 3.00 2.35 2.58 1.82
±SD 1.00 1.05 0.00 1.06 0.90 1.19
Amelanotic lesions
n of 49 47 48 47 28 44 25
mean CS 1.44 1.98 2.90 2.30 2.53 1.65
±SD 1.21 1.00 0.31 0.97 0.94 1.27
Melanotic lesions
n of 169 159 167 164 130 154 124
mean CS 1.84 1.63 2.88 1.98 2.17 1.48
±SD 1.13 1.22 0.32 1.23 1.13 1.30

Abbr.: n, number; CS, conspicuity score; SD, standard deviation; T1w, non-enhanced T1-weighted; T2w, T2-weighted; ceT1w, contrast-enhanced T1-weighted; SWI, susceptibility-weighted imaging; FLAIR, fluid-attenuated inversion recovery; DWI, diffusion-weighted imaging. Total number of lesions with confirmed melanotic / amelanotic primary tumor histology was 218/720 lesions overall.