Skip to main content
. 2018 Mar 29;13(3):e0194798. doi: 10.1371/journal.pone.0194798

Fig 6. Knock down of hepatic Inhbe mRNA in db/db mice caused a switch from carbohydrates to fats as the respiratory substrate and increased fat metabolism.

Fig 6

(A) Average energy daytime and nighttime respiratory quotients (RQ) on day 8 after the first dosing in the siNON- (n = 4) and siINHBE-treated groups (n = 4). (B) RQ values over a 24-h period on day 8 after the first dosing in the siNON- (n = 4) and siINHBE-treated groups (n = 4). (C) Average energy expenditure (EE) in the siNON- (n = 4) and siINHBE-treated groups (n = 4) during the daytime and nighttime periods of day 8 after the first dosing. (D) Average locomotor activity in the siNON- (n = 4) and siINHBE-treated groups (n = 4) during the daytime and nighttime periods of day 8 after the first dosing. (E) Plasma total ketone bodies (TKB) on days 2 (n = 6 for each group), 7 (n = 6 for each group), and 14 (n = 10 for each group) after the first dosing. Data are expressed as mean ± SEM. Differences between the two groups were assessed by unpaired t-test. **: P < 0.01, *: P < 0.05.