Table 1.
Pathologic characteristics in nonvaccinated and BCG-vaccinated rhesus and cynomolgus monkeys
| Treatment | Animal* | Lung disease† | Lymphadenopathy‡ | Hematogenous spread |
|---|---|---|---|---|
| None | R1 | 5 | 2 | Yes |
| R2 | 4 | 1 | Yes | |
| R3 | 3 | 3 | No | |
| BCG | R4 | 3 | 2 | No |
| R5 | 3 | 3 | No | |
| R6 | 4 | 2 | No | |
| None | C1 | 2 | 2 | No |
| C2 | 3 | 2 | No | |
| C3 | 3 | 3 | No | |
| BCG | C4 | 1§ | 0 | No |
| C5 | 1§ | 0 | No | |
| C6 | 1§ | 0 | No |
*
R rhesus and C cynomolgus monkeys.
†
Right lungs were scored according to proportion affected by disease. 1, <10%; 2, 10–30%; 3, 30–50%; 4, 50–70%; 5, 70–90%. Only in C3 was the left lung affected (2).
‡
Enlargement of tracheobronchial lymph nodes; 0, none; 1, mild; 2, moderate; 3, severe.
§
C4 had 10 granulomas, C5 had approximately 20 granulomas, and C6 had 1 granuloma.