Table 5. Resolving uncertainty–evaluating evidence.

Categories (Level 1)	Subcategories (Level 2)	Subcategories (Level 3)	Representative quotations
Evaluating evidence	Accepting new evidence	Observational CER RCT	“Definitely. Yes. Absolutely. I think I would still love to see a randomized trial, but I think if there was a large enough observational study that demonstrated (a treatment effect), it would be enough for me to change my practice.” (GN3) "I think an all-comers observational study probably wouldn’t change my management." (GN2)
	Devaluing observational studies	Generalizability	“The main thing I'd want to know about the methods section is how were patients selected for asymptomatic stroke. In the end, I think these people get scans for many reasons. Those reasons are heterogeneous.” (VN4)
	Skepticism about RCT feasibility	Feasibility	“I think it (an RCT) is actually impossible." (VN3)
		Equipoise	"I would have a little trouble telling someone not to take aspirin and a statin when I found a stroke on their head CT." (IN3)
		Recruitment