Table 1. Blood pressure, gas tension, and pH before ischemia reperfusion (IR), IR onset, and 1 h after IR.
| Sham | IR (DMSO) | SA10 | SA20 | SA20+LY | SA20+LN | SA20+nor-BIN | |
|---|---|---|---|---|---|---|---|
| MBP | |||||||
| Before IR | 66±6.78 | 65.4±4.67 | 63.2±4.72 | 63.6±4.88 | 64.2±4.76 | 65.4±6.43 | 64±6.12 |
| IR onset | 56±6.09 | 54.2±3.03 | 54.8±3.03 | 56.8±6.3 | 64.6±5.5 | 53±6.44 | 54.2±5.62 |
| 1 h after IR | 64.8±4.97 | 63.6±6.61 | 62.2±5.76 | 66.4±7.6 | 63.6±3.43 | 64.4±7.92 | 60.5±4.85 |
| PO2 | |||||||
| Before IR | 209.6±11.28 | 210.8±21.79 | 232.6±14.58 | 221.8±9.03 | 219.6±15.03 | 218.4±10.57 | 216.8±21.7 |
| IR onset | 125±13.71 | 113.6±9.78 | 138.8±18.29 | 132.2±19.21 | 115.8±13.26 | 117±35.7 | 137.4±35.6 |
| 1 h after IR | 210±8.91 | 217±18.48 | 226±14.84 | 215±13.95 | 197.4±20.18 | 186.6±14.93 | 201.6±611.23 |
| PCO2 | |||||||
| Before IR | 41.6±2.61 | 39.8±1.3 | 42±5 | 42.2±2.38 | 44±2 | 39.2±2.38 | 41.6±3.21 |
| IR onset | 44.28±3.91 | 45.6±2.3 | 43±2.12 | 38.4±1.15 | 42.8±3.8 | 41.8±3.03 | 42.2±4.43 |
| 1 h after IR | 41.2±3.96 | 41.2±5.4 | 41.4±4.03 | 44±3.32 | 43.4±2.89 | 40.8±3.34 | 42.8±2.77 |
| pH | |||||||
| Before IR | 7.4±0.039 | 7.388±0.02 | 7.421±0.026 | 7.398±0.039 | 7.385±0.031 | 7.402±0.036 | 7.408±0.025 |
| IR onset | 7.29±0.018 | 7.32±0.038 | 7.314±0.005 | 7.311±0.015 | 7.301±0.015 | 7.314±0.026 | 7.308±0.017 |
| 1 h after IR | 7.397±0.023 | 7.39±0.04 | 7.389±0.028 | 7.38±0.022 | 7.381±0.026 | 7.397±0.02 | 7.366±0.013 |
Data are reported as means±SD. Data were analyzed by one-way ANOVA followed by Tukey's test. No statistical difference was found among the different groups. LY: LY294002 (10 μM, injected); LN: L-NAME (10 μM, injected topically); IR (ischemia reperfusion control, DMSO): 1 μL/kg (iv); SA10: salvinorin A (10 μg/kg, iv); SA20: salvinorin A (20 μg/kg, iv); norBIN: norbinaltorphimine 1 μM (injected topically).