Table 2. Odds ratio and 95% confidence interval for associations of coronary artery disease and quintiles of thyrotropin (TSH).
| Quintiles of TSH | Crude | Model 1 | Model 2 |
|---|---|---|---|
| Euthyroid, SCHypo, SCHyper (n=767) | |||
| Coronary artery disease | |||
| 1st (0.00–0.95 mIU/L) | 1.35 (0.86–2.11) | 1.43 (0.89–2.31) | 1.29 (0.79–2.13) |
| 2nd (0.96–1.32 mIU/L) | 1.13 (0.72–1.77) | 1.05 (0.65–1.69) | 0.98 (0.59–1.60) |
| 3rd (1.33–1.78 mIU/L) | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) |
| 4th (1.79–2.71 mIU/L) | 1.48 (0.95–2.33) | 1.38 (0.86–2.22) | 1.38 (0.84–2.27) |
| 5th (2.72–35.5 mIU/L) | 0.99 (0.63–1.54) | 0.96 (0.60–1.54) | 0.95 (0.58–1.56) |
| P (1st vs 3rd) | 0.191 | 0.139 | 0.313 |
| Euthyroid subjects only (n=697) | |||
| Coronary artery disease | |||
| 1st (0.41–0.94 mIU/L) | 1.46 (0.91–2.35) | 1.57 (0.95–2.60) | 1.43 (0.84–2.43) |
| 2nd (0.95–1.28 mIU/L) | 1.22 (0.76–1.95) | 1.14 (0.69–1.88) | 1.02 (0.61–1.71) |
| 3rd (1.29–1.67 mIU/L) | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) |
| 4th (1.68–2.44 mIU/L) | 1.59 (0.99–2.55) | 1.56 (0.95–2.57) | 1.49 (0.89–2.52) |
| 5th (2.45–3.97 mIU/L) | 1.24 (0.78–1.99) | 1.18 (0.72–1.95) | 1.15 (0.69–1.93) |
| P (1st vs 3rd) | 0.117 | 0.079 | 0.192 |
SCHypo: subclinical hypothyroidism; SCHyper: subclinical hyperthyroidism. Model 1: adjusted for age, gender, race/skin color; Model 2: model 1 plus hypertension, diabetes mellitus, dyslipidemia, smoking, BMI, HDL-cholesterol, triglycerides, glomerular filtration rate by CKD-Epi (Chronic Kidney Disease Epidemiology Collaboration), and C-reactive protein.