Table 3. Odds ratio and 95% confidence interval for associations of segment involvement score (SIS) >4 and quintiles of thyrotropin (TSH) levels.
| Quintiles of TSH | Crude | Model 1 | Model 2 |
|---|---|---|---|
| Euthyroid, SCHypo, SCHyper (n=767) | |||
| SIS >4 | |||
| 1st (0.00–0.95 mIU/L) | 1.10 (0.59–2.06) | 1.16 (0.60–2.27) | 0.94 (0.46–1.90) |
| 2nd (0.96–1.32 mIU/L) | 0.97 (0.51–1.85) | 0.87 (0.44–1.71) | 0.75 (0.37–1.53) |
| 3rd (1.33–1.78 mIU/L) | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) |
| 4th (1.79–2.71 mIU/L) | 1.22 (0.66–2.26) | 1.07 (0.56–2.06) | 1.14 (0.58–2.24) |
| 5th (2.72–35.5 mIU/L) | 0.65 (0.32–1.31) | 0.71 (0.34–1.48) | 0.82 (0.38–1.73) |
| P (1st vs 3rd) | 0.767 | 0.659 | 0.855 |
| Euthyroid subjects only (n=697) | |||
| SIS >4 | |||
| 1st (0.41–0.94 mIU/L) | 0.91 (0.47–1.75) | 0.94 (0.47–1.91) | 0.68 (0.32–1.45) |
| 2nd (0.95–1.28 mIU/L) | 0.89 (0.46–1.72) | 0.77 (0.38–1.54) | 0.60 (0.29–1.25) |
| 3rd (1.29–1.67 mIU/L) | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) |
| 4th (1.68–2.44 mIU/L) | 1.05 (0.56–2.00) | 0.96 (0.49–1.87) | 0.90 (0.45–1.82) |
| 5th (2.45–3.97 mIU/L) | 0.60 (0.29–1.23) | 0.61 (0.29–1.28) | 0.61 (0.28–1.33) |
| P (1st vs 3rd) | 0.776 | 0.872 | 0.316 |
SCHypo: subclinical hypothyroidism; SCHyper: subclinical hyperthyroidism. Model 1: adjusted for age, gender, race/skin color; Model 2: model 1 plus hypertension, diabetes mellitus, dyslipidemia, smoking, BMI, HDL-cholesterol, triglycerides, glomerular filtration rate by CKD-Epi (Chronic Kidney Disease Epidemiology Collaboration), and C-reactive protein.