Figure 6. Hypoxia treatments regulated the expression of SIRT1 through miR-448 for participating in nerve cell apoptosis. A, Cell apoptosis analyzed by flow cytometry in AGE1.HN and PC12 cells treated with hypoxia, and transfected or co-transfected with NC or miR-448 inhibitor or si-control or si-SIRT1. *P<0.05 vs NC. #P<0.05 vs si-control (t-test). B, Cell apoptosis analyzed by flow cytometry in AGE1.HN and PC12 cells transfected with pre-NC or miR-448 mimic. Data are reported as means±SD. *P<0.05 vs pre-NC. #P<0.05 vs pcDNA (t-test). NC: negative control.
