Figure 4. Dietary blueberry extract supplementation in combination with chloroquine extended the survival of mice with AML.
C57BL/6J mice were engrafted with the murine AML cell line C1498 (1×106 cells/mouse by retro-orbital injection) and survival was monitored after mice were given a crude blueberry preparation to eat (25 mg/mouse/week) (line with upside down triangles), chloroquine in the drinking water (25 μM sweetened with 1% w/v glucose to alleviate bitterness) ad libitum (line with right side up triangles), or a combination of both (line with circles), or control water alone (line with squares), starting one week following engraftment (Mantel-Cox Logrank tests: Males & Females together, p=0.0263, n≥14/group; Males only, not significant at p=0.1225, n≥7/group; Females only, p=0.0479, n≥7/group).