Figure 1.

Lower pre- and post-donation eGFR in donors with high-risk APOL1 genotype than low-risk APOL1 genotype. Part A shows that the predonation and postdonation eGFRs were lower in donors carrying two APOL1 renal risk alleles (or high-risk genotype) than those carrying zero or one APOL1 renal risk allele (or low-risk genotype). Part B shows that a greater fraction of donors with two APOL1 renal risk alleles (high-risk genotype) had postdonation eGFR<60 ml/min per 1.73 m². eGFR was calculated via the CKD-EPI formula.