Figure 9.

NBCe1-A deletion alters PEPCK immunolabel expression in the proximal tubule under basal conditions and in response to acid-loading. Representative low and high magnification micrographs of PEPCK immunolabel in the kidneys of WT and KO mice on the normal diet (basal) and after acid loading. Top row shows low-power micrographs of kidneys in each of the four experimental group. Second row shows high-power micrographs from the cortical labyrinth showing PCT. Third row shows high-power micrographs from the medullary ray in the cortex, showing cortical PST. Bottom row shows the OSOM with outer medullary PST segments. Findings are representative of results in four mice fed normal diet and six mice after acid loading in each genotype. * indicates proximal tubule.