Table 1.
Basal physiologic parameters in adult NBCe1-A KO mice
| Parameter | WT | KO | P Value |
|---|---|---|---|
| Weight | 22.5±0.6 (31) | 17.3±0.7 (25) | <0.001 |
| Daily food intake, g | 10.0±0.2 (31) | 9.6±0.3 (25) | NS |
| Urine pH | 6.09±0.06 (30) | 5.15±0.09 (25) | <0.001 |
| Urine ammonia, µmol/d | 85.0±10.7 (29) | 120±18.2 (25) | NS |
| Urine ammonia, µmol/g body wt per day | 3.85±0.50 (29) | 6.61±0.76 (25) | <0.05 |
| Urine titratable acid, µmol/d | 82±13 (8) | 194±32 (8) | <0.01 |
| Urine net acid excretion, µmol/d | 149±25 (8) | 362±75 (8) | <0.05 |
| Serum Na+, mmol/L | 151±1 (8) | 149±1 (8) | NS |
| Serum K+, mmol/L | 3.78±0.08 (8) | 4.03±0.44 (8) | NS |
| Serum HCO3−, mmol/L | 22.7±1.2 (8) | 12.0±0.8 (8) | <0.001 |
| BUN, mg/dl | 27±2 (7) | 27±3 (8) | NS |
| Urea clearance, µl/min | 203±33 (7) | 134±15 (8) | NS |
Values are mean±SEM. Numbers in parentheses are numbers of animals in each group.