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A1/A2ΔE16.5 and Tie2ΔE16.5 mutants have urine concentration defects. Total urine collected within a 24-hour period showing increased urine output from (A) A1/A2ΔE16.5 and (B) Tie2ΔE16.5 mutants. Osmolality measurements on urine samples showing dilute urine production from (C) A1/A2ΔE16.5 and (D) Tie2ΔE16.5 mutants. Statistically significant means (P<0.05) are denoted by asterisks.
