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. 2018 Jan 4;8(1):3. doi: 10.3390/metabo8010003
I : Set of all metabolites;
J : Set of all fluxes where reversible reactions are treated as two unidirectional reactions;
cj : Vector selecting unidirectional flux components with products in core (e.g., from reactions with non-currency metabolite products in the core, as well as reversible reactions with reactants in core);
Sij : Stoichiometry matrix;
vj : Flux value of reaction jJ;
ubj,lbj : Upper and lower bounds for j.