| I | : Set of all metabolites; |
| J | : Set of all fluxes where reversible reactions are treated as two unidirectional reactions; |
| : Vector selecting unidirectional flux components with products in core (e.g., from reactions with non-currency metabolite products in the core, as well as reversible reactions with reactants in core); | |
| : Stoichiometry matrix; | |
| : Flux value of reaction ; | |
| : Upper and lower bounds for j. |