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. 2018 Mar 13;8(1):21. doi: 10.3390/metabo8010021

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Application of nanoparticles with different surface modifications for selective molecular sensing based on NMR magnetization transfer or diffusion-ordered spectroscopy (DOSY). The interaction strength and specificity between the surface coating ligands and organic molecule analytes can be modulated via rationally-designed nanoparticle surface modifications, reflecting the potential of this method for the selective detection and identification of metabolites in a complex biological mixture. Reprinted with permission from [43].