Table 1. Summary of MSC-‘exosome’ based therapeutics.

Ultracentrifugation (UC). 100,000 – 120,000 × g (100K – 120K × g). SEC (size exclusion chromatography). ExoQuick and ExoELISA refer to a commercially available exosome isolation kit and CD63 capture (exosome) ELISA, respectively (Systems Biosciences,CA). Table adapted from (72).

Disease	MSC-product ‘nomenclature’	Final isolation step	Dose assessment	Dose	Ref
Bronchopulmonary dysplasia	Exosomes	Density Cushion	Cell equivalent	0.5 × 106	(60)
Pulmonary hypertension	Exosomes	SEC	Protein	0.1 – 10 μg	(58)
Pulmonary hypertension	Exosomes	UC (100K × g)	Protein	25 μg	(81)
Acute lung injury	Microvesicles	UC (100K × g)	Cell equivalent	1.5 × 10	(82)
Silicosis	Exosomes	Sucrose gradient	Protein	40 μg	(83)
Pneumonia	Microvesicles	UC (100K × g)	Cell equivalent	9 × 10	(84)
Myocardial infarction	Exosomes	ExoQuick	Cell equivalent	4 × 10	(85)
Myocardial infarction	EVs	UC (100K × g)	Protein	80 μg	(86)
Myocardial infarction	Exosomes	ExoQuick	Protein	80 μg	(87)
Ischemia/reperfusion	Exosomes	HPLC	Protein	0.4 μg	(54)
Ischemia/reperfusion	Exosomes	HPLC	Protein	0.4 – 0.8 μg	(55)
Traumatic brain injury	EVs	Anion exchange chromatograph	Protein	30 μg	(88)
Laser-induced retinal injury	Exosomes	UC (110K × g)	Protein	10 μg	(89)
Optical nerve crush	Exosomes	UC (100K × g)	ExoELISA	3 × 10	(90)
Stroke	EVs	UC (110K × g)	Cell equivalent	2 × 10	(91)
Stroke	Exosomes	UC (100K × g)	Protein	100 μg	(92)
Cardiotoxin injury	EVs	UC (100K × g)	Protein	5 μg	(61)
Drug-induced liver injury	Exosomes	UC (100K × g)	Protein	0.4 μg	(93)
Liver fibrosis	Exosomes	UC (100K × g)	Protein	250 μg	(94)
Colitis	EVs	UC (100K × g)	Protein	50 – 200 μg	(95, 96)
Wound healing	Exosomes	UC (100K × g)	Protein	160 μg	(97)
Wound healing	Exosomes	UC (120K × g)	Protein	100 μg	(96)
Ischemia/reperfusion	Microvesicles	UC (100K × g)	Protein	100 μg	(98)
Acute kidney injury	Microvesicles	UC (100K × g)	Protein	100 μg	(99)