Fractional anisotropy (A–C) and mean diffusivity (D–F) measurements of models with histology informed geometry from control (black circles), cardiotoxin (red squares), tenotomy (purple diamonds), botox (blue upside down triangles), and denervation (green triangles) skeletal muscle as a function of average muscle fiber diameter. Diffusion measures were made with single-echo (A, D), and the short (B, E) and long (C, F) T2 compartments from the multi-echo DTI sequence.