Table 2.

Association of demographics and common neuropathologies with late life cognitive decline

Variable	Cognitive level†	Rate of cognitive decline
Age at death	0.003 (0.005),0.526	0.002 (0.0005), <0.001
Female sex	0.111 (0.070), 0.112	0.015 (0.007), 0.018
Education	0.037 (0.009), <0.001	0.001 (0.0008), 0.111
AD	−0.679 (0.070), <0.001	−0.062 (0.006), <0.001
Macroscopic infarcts	−0.280 (0.069), <0.001	−0.025 (0.006), <0.001
Cerebral amyloid angiopathy	−0.265 (0.068), <0.001	−0.018 (0.006), 0.005
TDP-43	−0.347 (0.072), <0.001	−0.032 (0.007), <0.001
Atherosclerosis	−0.281 (0.070), <0.001	−0.021 (0.007), 0.001
Arteriolosclerosis	−0.240 (0.071), <0.001	−0.024 (0.007), <0.001
Microinfarcts	−0.032 (0.070), 0.647	0.006 (0.006), 0.366
Cortical Lewy bodies	−0.592 (0.094), <0.001	−0.062 (0.009), <0.001
Hippocampal sclerosis	−0.685 (0.110), <0.001	−0.038 (0.010), <0.001

^†level proximate to death; statistics presented are Estimate (Standard error), p-value.