Table 2. Positive interaction between BRAF mutation and LEF1.
The interaction between BRAF mutation and LEF1 gene expression is evaluated by linear regression with PLX4720 efficacy as the outcome. The t-value is defined as regression coefficient divided by the standard error, and the p-value is calculated by the two-sided Student’s t-test.
See also Table S1.
| Coef | Stderr | t-value | p-value | |
|---|---|---|---|---|
|
| ||||
| BRAF.V600E | 0.16107 | 0.0107 | 15.06 | 2.90E-42 |
| LEF1 | 0.00282 | 0.00264 | 1.07 | 2.86E-01 |
| LEF1*BRAF.V600E | 0.02849 | 0.00793 | 3.59 | 3.62E-04 |
| CARE score | 0.03131 | 0.00748 | 4.19 | 3.37E-05 |