Figure 3.
Schematic structure of the EK gene. The 5′-region of EK gene is shown as an open box, containing exons 3–6 of the total 25 exons of canonical EK (TMPRSS15; accession number NM_002772.2), and the additional exons of isoforms X1–X4 (XM_011529654.1–011529659.1), deduced from the GenBank data, are shown as solid black boxes. The three transcript variants (XM_011529654.1–011529656.1) encode the same isoform X1 with different 5′ untranslated regions. The boxed X2 isoform (XM_011529657.1) was actually cloned from Huh7 liver cells, and contains an additional 90-bp exon between exons 3 and 4 of canonical EK.