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. 2018 Mar 23;9:252. doi: 10.3389/fphar.2018.00252

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Copyright © 2018 Yang, Chen, Wang, Deng, Huang, Ma, Song, Du, Huang, Wen, Ren and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Kurarinone dose- and time-dependently provoked human A549 cell apoptosis in vitro. (A) Structure of kurarinone is shown. (B) HPLC chromatogram of kurarinone (C) A549, NCI-H1975 and the human bronchial epithelial BEAS-2B cells were incubated with 0, 5, 10, 15, 20 μg/mL of kurarinone for 24 h. (D) IC₅₀ values of each cell line were calculated. (E–G) A549 cells were treated with indicated concentrations of kurarinone. After 12, 24, 48 h, cell viability was examined by MTT. The data are shown as the means ± SD of three independent experiments. ^∗P < 0.05 compared to control, ^∗∗P < 0.01 compared to control, ^∗∗∗P < 0.001, compared to control.