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. 2018 Mar 23;9:252. doi: 10.3389/fphar.2018.00252

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Copyright © 2018 Yang, Chen, Wang, Deng, Huang, Ma, Song, Du, Huang, Wen, Ren and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Kurarinone inhibited A549 xenograft growth in nude mice. Forty female BALB/c nude mice received an injection of A549 cells and were divided into four groups. Kurarinone and CDDP were administered at a dose of 20, 40 mg/kg/day and 2.5 mg/kg every 2 days. On day 27, mice were sacrificed and tumor xenografts were excised completely from tissues. (A,B) The representatives of the control and kurarinone-treated mice and tumors. (C–E) Statistical analyses demonstrated the tumor weights, tumor volume, and body weight. The data are shown as the means ± SD of three independent experiments. ^∗P < 0.05 compared to control, ^∗∗P < 0.01 compared to control, ^∗∗∗P < 0.001, compared to control.