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. 2018 Mar 23;9:252. doi: 10.3389/fphar.2018.00252

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Copyright © 2018 Yang, Chen, Wang, Deng, Huang, Ma, Song, Du, Huang, Wen, Ren and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Kurarinone inhibited the in vivo tumor growth through activating the intrinsic apoptosis pathway. (A,B) Nude mice bearing A549 xenograft were sacrificed after treatment with kurarinone (20 and 40 mg/kg/day), and the tumors were harvested for TUNEL assay. The brown stains in Tunel assay in kurarinone treated tumor tissue suggested that kurarinone induced apoptosis in tumor of treated mice. (C–E) The tumors dissected from the nude mice were homogenated and subjected to the total protein extraction followed by western blot analysis to detect the expressions of Bcl-2, Bax, Bax, and the cleaved-caspases. All data are shown as the means ± SD of three independent experiments. ^∗P < 0.05 compared to control, ^∗∗P < 0.01 compared to control, ^∗∗∗P < 0.001, compared to control.