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. 2018 Mar 23;12:74. doi: 10.3389/fncel.2018.00074

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Copyright © 2018 Liu, Vollmer, Fernandez, Dweik, Kim and Doré.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ginseng pretreatment improves expression levels of Nrf2 downstream cytoprotective proteins in WT mice but not in Nrf2^−/− mice at 24 h after pdMCAO. (A) Western Blot of HO1, NQO1, SOD2 and GPX1 protein expressions on day 1 after pdMCAO in peri-infarct tissue of different groups. (B–E) Quantifications of above markers in (A). Statistical analyses were carried out using one-way or two-way ANOVA. Data are presented as mean ± SEM. n = 4–5 per group. *p < 0.05, **p < 0.01, ^#p < 0.05, ^Δp < 0.05, ^ΔΔp < 0.01. HO1, Heme oxygenase 1; NQO1, NAD(P)H:Quinone Oxidoreductase 1; SOD2, superoxide dismutase 2; GPx, glutathione peroxidase.