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. 2018 Mar 29;8:5396. doi: 10.1038/s41598-018-23682-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Genotype comparison map showing haematopoietic stem cell transplantation (HSCT) donor-recipient pairs with large genomic fragments of mismatched single nucleotide polymorphisms (SNPs) in the major histocompatibility complex (MHC) segment. The mismatched HSCT pairs are shown in discovery order on the X-axis. Green depicts matched SNPs, yellow depicts mismatched and red indicates missing results or poor quality SNPs. Physical map of the MHC region with selected marker genes is shown on the left. The vertical axes in the similarity plot show the positions of SNP having a mismatch in at least one pair. (a) Identical-by-state status of 5137 SNPs covering the entire MHC gene complex by an Immunochip array in 15 HSCT sibling pairs (study cohort 1). The Y-axis shows a segment of chromosome 6p21 encompassing positions 29,002,062 bp (telomeric to HLA-F) to 33,496,714 bp (centromeric to HLA-DPB1). (b) Identical-by-state status of 12 HSCT pairs sequenced for the 4.5 Mbp MHC region (study cohort 2). The Y-axis shows a segment of chromosome 6p21 encompassing positions 29,000,825 bp (telomeric to HLA-F) to 33,477,140 bp (centromeric to HLA-DPB1).