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. 2018 Mar 29;8:5396. doi: 10.1038/s41598-018-23682-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Allelic mismatching in cohort 2 of 34 genes located in the major histocompatibility complex region. The genes are listed from the telomeric end (HLA-F) to the centromeric end (HLA-DPB2). The classical HLA-A, -B, -C, -DRB1 and -DQB1 genes are highlighted. The eight uppermost haematopoietic stem cell transplantation pairs are 5/6 HLA-matched, and pairs 5672 and 6907 are 6/6 HLA-matched siblings. Alleles of the 34 genes are assigned based on exon sequence analysis at six-digit resolution level. Allelic mismatching that results in amino acid change is depicted in grey. Mismatching that remains at the DNA level (silent mutations) is marked with stripes.