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. 2018 Mar 29;8:5396. doi: 10.1038/s41598-018-23682-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Trend toward higher risk for graft-versus-host disease (GvHD) along increasing number of nucleotide mismatches between haematopoietic stem cell transplantation (HSCT) donor-recipient pairs in study cohort 1. The donor-recipient pairs are divided into low and high mismatch groups according to the total number of MHC region genotype differences between each pair. Similarly, each pair is also assigned into either aGvHD positive or negative group according to the recipient’s clinical GvHD gradus. The mismatch and GvHD categorized data are then arranged into a contingency table to calculate the odds ratio (OR). The mismatch threshold value, defined as the natural logarithm of the number of total SNP genotype differences per each HSCT sibling pair, is varied from 0 to 6 and the corresponding odds ratio is calculated for each threshold value. Thus, each data point represents an odds ratio at a particular threshold value. Moreover, two alternate definitions for the GvHD negative status are used: grade 0 (no) or grades 0–2 (no/limited) in acute GvHD, and no GvHD or no/limited in the chronic GvHD. The plots show the odds ratios (y-axis) against the varying mismatch threshold values (x-axis). (a) Acute (n = 91) and (b) chronic (n = 62) GvHD for cohort 1, and (c) acute (n = 85) and (d) chronic (n = 56) GvHD for fully HLA A-B-DRB1 matched cohort 1 pairs. Pairs with zero MHC mismatches are omitted. Linear regression lines are shown for both GvHD negative groups by their corresponding colours. Correlation is calculated by Kendall’s rank correlation. aGvHD, acute graft-versus-host disease; cGvHD chronic graft-versus-host disease; OR, odds ratio.