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. 2018 Mar 29;8:5405. doi: 10.1038/s41598-018-23731-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of the IR response on the cell cycle. (A) DNA content analysis of PI-stained cells. The red histograms represent the IR-treated cells and the gray histograms represent the non-treated cells. This assay was performed in triplicate. Dotted lines represent the peak of fluorescence intensity of G1/S cells (left peak) and of G2/M cells (right peak). (B) A measurement of N/K patterns through the DAPI-staining of IR-treated and non-treated cells. The data represent the average of three independent experiments and the error bars represent the standard deviation. n > 100 for each sample. (C) Fluorescence intensity of γH2A, according to the cell cycle phases (G1/early S and late S/G2). Note that these cell cycle phases were estimated based on the duplication of the kinetoplast (K) and nucleus (N) during the cell cycle. The data represent the average of 50 analyzed cells from the G1/S phase and 15 analyzed cells from the late S/G2 phase.