Figure 1.

Adhesion and activation of platelets on collagen. (a) Washed human platelets and (b) wild type (WT) or CypD^−/− (KO) washed murine platelets were placed on collagen-coated glass surfaces and simultaneously activated with 25 nM thrombin in the presence of additives as indicated (ROS, CsA). SEM images were taken following fixation with glutaraldehyde. The arrowheads mark representative cases of membrane blebbing and shedding, the arrows point to membrane fragmentation and disintegration. Scale bar = 1 µm.