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. 2018 Mar 29;8:5374. doi: 10.1038/s41598-018-23624-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Representative binding modes of the 2 × C18 diester to Mincle. Mincle is shown in blue surface presentation with the hydrophobic groove in yellow. Hydrophobic residues lining the groove are shown in orange and are labelled. The glycolipid is shown in stick presentation with the trehalose, F1 and F2 chains are colored in black, cyan, and green, respectively. See text for a detailed description of the binding modes (a–d) and the Supplementary movie for the dynamic nature of the interaction.