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. 2018 Mar 29;9:1286. doi: 10.1038/s41467-018-03421-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Arterial function. Effect of 6 weeks of oral placebo vs. NR supplementation on a aortic pulse wave velocity (PWV) as a whole (N = 24; 12 per group), b subgroups of individuals with normal (N = 11) vs. above-normal (N = 13) baseline BP); c carotid artery compliance (CC) and d brachial artery flow-mediated dilation (FMD) in the overall groups (N = 24; 12 per group). Data are mean ± SD. P-values reported in individual bars based on one-tailed paired t-test (panels a, c, and d only) and an adjusted alpha level set at 0.006