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. 2018 Feb 23;15(5):6131–6136. doi: 10.3892/ol.2018.8110

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — c-Met was identified as a direct target gene of miR-148a-3p. (A) A conserved binding site in the 3′UTR region of c-Met was identified using the TargetScan program. (B) The dual luciferase reporter assay demonstrated that miR-148a-3p significantly suppressed the relative luciferase activity of pmirGLO-c-Met-3′UTR compared with the blank vector. (C) mRNA levels of c-Met were significantly decreased following transfection of miR-148a-3p mimics. (D) Protein levels of c-Met were also decreased by miR-148a-3p overexpression. **P<0.01 and ***P<0.001 vs. NC. c-Met, tyrosine-protein kinase Met; UTR, untranslated region; miR-148a-3p, microRNA-148a-3p; RLU, relative luciferase units; NC, negative controls; Mut, mutated.