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. 2018 Feb 23;15(5):6131–6136. doi: 10.3892/ol.2018.8110

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Decreased expression of MET inhibited the malignancy of EOC. (A) Levels of c-Met mRNA were significantly increased in EOC tissue. (B) Western blot analysis of siRNA targeting c-Met. (C) Silencing of c-Met decreased the proliferation of SKOV3 cells. (D) The invasiveness of EOC cells was also inhibited following the silencing of c-Met (magnification, ×40). **P<0.01 and ***P<0.001 vs. NC. MET, c-Met proto-oncogene; EOC, epithelial ovarian cancer; c-Met, tyrosine-protein kinase Met; NC, negative control; si-c-Met, siRNA targeting c-Met; OD, optical density; siRNA, small interfering RNA; 148i, miR-148a-3p inhibitor; si-c-Met+148i, siRNA targeting c-MET co-transfected with an miR-148a-3p inhibitor.