Table III.
Potential therapeutic targets in medulloblastoma tumors, including the top ten upregulated and downregulated differentially expressed genes in the 5 subgroups of medulloblastoma.
| Fold change vs. control cerebellar tissue | |||||
|---|---|---|---|---|---|
| Gene symbol | WNT | SHH | G3 | G4α | G4β |
| SOX11 | 50.4508 | 159.2550 | 114.7920 | 214.6350 | 157.7430 |
| LHX2 | 19.0600 | 18.1300 | 62.1164 | 118.7020 | 45.9915 |
| KIAA0101 | 89.8103 | 97.5187 | 119.3500 | 106.7370 | 70.2860 |
| TOP2A | 97.4276 | 74.4959 | 95.3006 | 89.4034 | 56.8238 |
| TMSB15A/B | 27.3665 | 131.5370 | 36.4977 | 80.2035 | 74.1441 |
| DACH1 | 25.9512 | 23.0074 | 28.4259 | 74.5587 | 41.3941 |
| SOX4 | 13.2496 | 15.9908 | 25.3652 | 64.0049 | 53.1116 |
| DACH1 | 19.2667 | 14.5598 | 16.1719 | 61.2870 | 21.7303 |
| RRM2 | 48.8038 | 47.4022 | 75.8280 | 55.5282 | 46.5205 |
| IGFBPL1 | 68.8801 | 60.7771 | 10.3575 | 50.0114 | 48.5435 |
| ITPR1 | −26.0343 | −27.0244 | −78.6472 | −58.7188 | −47.0085 |
| SYT1 | −8.2123 | −8.1780 | −25.8050 | −62.9443 | −37.5653 |
| SPHKAP | −98.0768 | −21.4717 | −91.2947 | −64.4953 | −42.0679 |
| PDE1A | −119.2340 | −13.2837 | −128.5230 | −66.5903 | −25.8941 |
| CDR1 | −78.4458 | −66.2995 | −75.0443 | −83.1560 | −78.4922 |
| CBLN3 | −82.5110 | −97.7424 | −131.9180 | −97.2893 | −71.7417 |
| CRTAM | −142.5620 | −119.6880 | −176.9190 | −98.6054 | −91.3960 |
| CALB1 | −90.1248 | −100.8540 | −50.7010 | −121.3370 | −113.9070 |
| PVALB | −125.1260 | −90.7036 | −243.5880 | −175.7630 | −113.7100 |
| GABRA6 | −254.6810 | −245.7720 | −171.3970 | −192.7920 | −133.8460 |
G3, group 3 medulloblastoma; G4, group 4 medulloblastoma.