Table I.
Association between LINE-1 methylation and clinicopathological features.
| LINE-1 methylation (%) | ||||
|---|---|---|---|---|
| Feature | N (%) | Mean | SEM | P-value |
| Age, years (mean ± SD) | 65.4±11.0 | |||
| <65 | 40 (52.6) | 69.5 | 1.6 | 0.695 |
| ≥65 | 45 (47.4) | 69.1 | 1.2 | |
| Sex | ||||
| Male | 65 (68.4) | 68.8 | 1.2 | 0.366 |
| Female | 30 (31.6) | 70.4 | 1.6 | |
| Tumor location | ||||
| Upper | 27 (28.4) | 71.6 | 1.6 | 0.056 |
| Lower | 68 (71.6) | 68.4 | 1.2 | |
| Background atrophy | ||||
| No | 68 (71.6) | 69.5 | 1.2 | 0.514 |
| Yes | 27 (28.4) | 68.7 | 1.7 | |
| Background intestinal metaplasia | ||||
| No | 12 (12.6) | 74.0 | 1.6 | 0.042 |
| Yes | 83 (87.4) | 68.6 | 1.1 | |
| Tumor differentiation | ||||
| Differentiated | 47 (49.5) | 66.7 | 1.6 | 0.034 |
| Undifferentiated | 48 (50.5) | 71.8 | 0.9 | |
| Lauren's histologic classification | ||||
| Intestinal | 67 (70.6) | 67.6 | 1.3 | 0.014 |
| Diffuse | 14 (14.7) | 72.9 | 1.6 | |
| Mixed | 14 (14.7) | 73.7 | 1.6 | |
| T classification | ||||
| T1/T2 | 29 (30.5) | 71.1 | 1.6 | 0.290 |
| T3/T4 | 66 (69.5) | 68.5 | 1.2 | |
| N classification | ||||
| N0 | 29 (30.5) | 69.9 | 1.5 | 0.796 |
| N1 | 24 (25.3) | 68.2 | 2.3 | |
| N2 | 17 (17.9) | 68.1 | 2.4 | |
| N3 | 25 (26.3) | 70.3 | 1.9 | |
| Tumor stage | ||||
| I (A+B) | 20 (21.1) | 69.0 | 2.0 | 0.111 |
| II (A+B) | 20 (21.1) | 73.0 | 1.5 | |
| III (A+B+C) | 46 (48.4) | 68.0 | 1.6 | |
| IV | 9 (9.5) | 73.0 | 2.4 | |
LINE-1, long interspersed element-1; SEM, standard error of the mean; SD, standard deviation.