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(A) Functional domains of the AR. (B) Biology of the androgen receptor signaling pathway. DBD, DNA binding domain; LBD, Ligand binding domain; H, hinge region, AF-1, transcriptional activating function 1; AF-2, transcriptional activating function 2; NLS, nuclear localization signal; NES, nuclear export signal; AR, androgen receptor; DHT, dihydrotestosterone; HSP, heat-shock protein; P, phosphorylation.
