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Androgen receptor-dependent mechanisms of resistance in hormone-sensitive prostate cancer leading to castration-resistance. AR, androgen receptor; wtAR, wild-type AR; AR-V, AR splice variants; mutAR, mutated AR; T, testosterone; DHT, dihydrotestosterone; DHEA, dehydroepiandrosterone; STAT3, signal transducer and activator of transcription 3; MAPK, mitogen-activated protein kinase; HSP, heat-shock protein.
