Figure 4.

Serum anti-HBsAg antibodies detected in mice fed HBsAg transgenic but not in mice fed nontransformed potatoes. (A) Mice were fed HB114–16 potatoes + CT at weeks 0, 1, and 2; a primary antibody response was elicited, and a strong memory response was obtained when the mice were boosted with a subimmunogenic dose of yeast-derived alum-adsorbed rHBsAg. (B) Mice were fed nontransformed FL1607 potatoes + CT at weeks 0, 1, and 2, then boosted with a subimmunogenic dose of yeast-derived alum-adsorbed rHBsAg. No antibody response was elicited.