Figure 2.

Schematic representation of Akt-substrates involved in the regulation of the cellular radiation response. Akt mediates several subcellular processes, e.g., survival, growth and phosphorylation by phosphorylating different target proteins. Phosphorylation of different Akt targets involved in survival (orange), proliferation (green) and growth (blue) leads to an activation or inhibition of their function. Arrows depict activating phosphorylation whereas blocking lines depict inhibitory phosphorylation. Nuclear translocation of p21/27 and FOXO3A is inhibited upon phosphorylation by Akt depicted by red cross.