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. 2018 Mar 20;10(3):82. doi: 10.3390/cancers10030082

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Schematic overview of the role of protein tyrosine phosphatases (PTPs) in hepatocellular carcinoma (HCC). EGFR: epidermal growth factor receptor; PI3K: phosphotidylinsitol-3-OH kinase; Akt: alpha serine/threonine-protein kinase; Mtor: mechanistic target of rapamycin; JAK: janus kinase; STAT3: signal transducer and activator of transcription-3; SHP: Src homology 2-containing phosphotyrosine phosphatase; PTPRO: protein tyrosine phosphatase receptor type O; PTPN: protein tyrosine phosphatase non-receptor; Ras: rat sarcoma; Raf: Rapidly accelerating fibrosarcoma; MEK: MAP kinase kinases; ERK: extracellular signal-regulated kinase; MET: mesenchymal-epithelial transition factor; PTP1B: protein tyrosine phosphatase 1B; PTPRF: protein tyrosine phosphatase receptor type F; DUSP1: dual specificity phosphatase 1; RASA1: Ras p21 protein activator 1; PITX: pituitary homeobox; PRL-1: phosphatase of regenerating liver-1; GSK3β: glycogen synthase kinase 3β.