Fig. 5.

Illustration of PIM and SGK1-mediated resistance to PI3K inhibitors. a The relevant subnetwork of the full network shown in Fig. 3. PIM shares four targets of AKT (compare blue and red edges), while SGK1 shares two (green edges). Their post-translational regulation is different from AKT’s: SGK1 is activated by different pools of PDK1 and mTORC2 than AKT, while PIM is constitutively active. b Time course of node activity in response to PI3K inhibition at time = 2 in cells with full activity of PIM (top) or reduced PIM activity (10% chance of inactive PIM at any time step) (bottom). c Time course of node activity in response to PI3K inhibition at time = 2 in cells with constitutive PDK1 and SGK1 activity. The symbol legend applies to both B and C