Table 3.
Single-node interventions which in combination with PI3K inhibitors yield an increase in Apoptosisnorm from 0.7 and/or a decrease in Proliferationnorm from 0.25
| Perturbation | Apoptosisnorm | Proliferationnorm | Mechanism |
|---|---|---|---|
| BCL2 = 0 | 1.00 | 0.25 | Apoptosis |
| ER_transcription = 0 | 0.84 | 0.00 | ER |
| ER_transcription < 2 | 0.84 | 0.13 | ER |
| Fulvestrant = 1 | 0.83 | 0.00 | ER |
| KMT2D = 0 | 0.83 | 0.13 | ER |
| FOXA1 = 0 | 0.83 | 0.13 | ER |
| BCL2_T = 0 | 0.81 | 0.25 | Apoptosis |
| MCL1 = 0 | 0.75 | 0.25 | Apoptosis |
| mTORC1 = 0 | 0.74 | 0.25 | mTORC1 |
| Everolimus = 1 | 0.73 | 0.25 | mTORC1 |
| cycD_CDK46 = 0 | 0.70 | 0.00 | Proliferation |
| Palbociclib = 1 | 0.70 | 0.00 | Proliferation |
| pRb = 0 | 0.70 | 0.00 | Proliferation |
| E2F = 0 | 0.70 | 0.00 | Proliferation |
| MYC = 0 | 0.70 | 0.00 | ER |
| pRb < 2 | 0.70 | 0.13 | Proliferation |
| cycD_CDK46 < 2 | 0.70 | 0.13 | Proliferation |
| MYC < 2 | 0.70 | 0.13 | ER |
| FOXO3 = 0 | 0.33 | 0.13 | AKT |
The entries are ordered by their effect on Apoptosis. Certain node perturbations that are equivalent in the network sense and lead to the same effect are grouped, specifically: ESR1 = OFF, ER = OFF, and ER_transcription = 0; ESR1 < 2 and ER_transcription < 2; PBX1 = OFF and FOXA1 = OFF; translation = OFF, S6K=OFF, EIF4F=OFF, and mTORC1 = OFF; cyclinD = 0, CDK4/6 = OFF, and cycD_CDK4/6 = 0; cyclinD < 2, and cycD_CDK4/6 < 2; FOXO3_Ub = ON and FOXO3 = OFF