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. 2001 Sep 25;98(20):11551–11556. doi: 10.1073/pnas.191363198

Figure 1.

Figure 1

(Left) Representative microphotographs of SENCAR mice skin sections obtained from experimental and control mice in the complete carcinogenesis experiment after a 4-week treatment with DMBA (A, 100 nmol of DMBA, twice per week), F035/DMBA (B, 1.0 mg of F035 followed by 100 nmol of DMBA, twice per week), and F060/DMBA (C, 1.0 mg of F060 followed by 100 nmol of DMBA, twice per week). (D, E, and F) Skin sections from control animals. (D) Acetone treatment only. (E) F035 treatment only (1.0 mg, twice per wk). (F) F060 treatment only (1.0 mg, twice per wk). Note the strong preventative effect of triterpenoid saponins F035 on epidermal hyperplasia in B. Hematoxylin/eosin (H&E) ×200. (Right) Representative microphotographs of SENCAR mice skin sections obtained from experimental mice in the complete carcinogenesis experiment after an 8-week treatment with DMBA alone (G, 100 nmol of DMBA, twice per wk), F035/DMBA (H, 1.0 mg of F035 followed by 100 nmol of DMBA, twice per week), and F060/DMBA (I, 1.0 mg of F060 followed by 100 nmol of DMBA, twice per week). (J–L) Skin sections obtained at 8 weeks from experimental mice in the initiation/promotion experiment. (J) Papilloma-like structure appearing at 8 weeks after a single application of DMBA (10 nmol) followed by twice per week TPA; (K) 10 nmol of DMBA once followed by twice per week F035/TPA. (L) Ten nanomoles once followed by twice per week F060/TPA. Note the strong preventative effect of triterpenoid saponins F035 on hyperplasia in H. H&E ×200.