Table 2.

F035 inhibition of papilloma development in complete carcinogenesis and initiation/promotion experiments in SENCAR mice

Treatment	Mice with papillomas at 12 wk, %	No. of papillomas per mouse at 12 wk	Mice with papillomas at 16 wk, %	No. of papillomas per mouse at 16 wk
Complete carcinogenesis
DMBA*	100	8.6  (0%)	100	10.6  (10%)
F035†/DMBA*	33	0.7  (0%)	42	2.4  (0%)
F060‡/DMBA*	100	8.2  (0%)	100	9.3  (10%)
Initiation/promotion
DMBA§/TPA	100	12.6  (30%)	100	20.6  (50%)
DMBA§/F035¶/TPA‖	39	1.45  (0%)	58	2.9  (0%)
DMBA§/F060**/TPA‖	100	18.2  (30%)	100	22.3  (51%)

The concentrations of the test compounds: 

^*, 100 nmol (2×/wk for 4 wk);  

^†, 1.0 mg (2×/wk for 4 wk);  

^‡, 1.0 mg (2×/wk for 4 wk);  

^§, 10 nmol (1×);  

^¶, 1.0 mg (2×/wk for 8 wk);  

^‖, 2 μg (2×/wk for 8 wk); 

^**, 1.0 mg (2×/wk for 8 wk). Shown in parentheses are % papillomas with aneuploidy.