Table 2.
Changes in Hemodynamics With Arterial Infusion of Tyramine and Phenylephrine—Protocol 1
| PLA | PROB | PLA | PROB | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Leg | ||||||||||
| Variable | TYR 0.3 | TYR 1.0 | TYR 0.3 | TYR 1.0 | PE 0.75 | PE 1.5 | PE 3.0 | PE 0.75 | PE 1.5 | PE 3.0 |
| Blood flow, % | −69.1±5.2 | −88.0±3.1 | −58.7±5.1* | −83.3±4.2 | −52.5±7.2 | −54.3±5.1 | −59.7±3.9 | −54.3±3.9 | −58.2±4.1 | −61.6±3.8 |
| Mean arterial blood pressure, mm Hg | 2±1 | 6±1 | 0±1* | 3±1* | 1±1 | 2±1 | 5±1 | 1±1 | 2±1 | 3±0 |
| Vascular conductance, % | −69.7±5.1 | −88.8±2.9 | −58.8±5.2* | −83.6±4.3 | −53.1±7.2 | −55.3±4.9 | −61.4±4.0 | −54.6±4.0 | −59.1±4.0 | −62.7±3.7 |
| Heart rate, bpm | 0±1 | 1±2 | −1±1 | 1±1 | −1±1 | 0±1 | 0±1 | 0±1 | 0±1 | −1±1 |
| Venous norepinephrine, nmol L−1 | 0.8±0.8 | 6.4±1.6 | 0.6±0.5 | 9.8±1.8 | … | … | … | … | … | … |
| Forearm | ||||||||||
| Variable | TYR 0.3 | TYR 1.0 | TYR 0.3 | TYR 1.0 | PE 0.75 | PE 1.5 | PE 3.0 | PE 0.75 | PE 1.5 | PE 3.0 |
| Blood flow, % | −32.8±7.4† | −60.0±8.0† | −34.4±8.0† | −64.2±6.9† | −42.5±4.9 | −55.9±5.9 | −71.5±4.7 | −36.3±6.2 | −50.3±6.6 | −68.2±5.1 |
| Mean arterial blood pressure, mm Hg | 0±1 | 1±1† | 1±0 | 1±1 | 1±0 | 1±1 | 1±1† | 0±1 | 1±1 | 1±1 |
| Vascular conductance, % | −32.8±7.7† | −60.2±8.5† | −35.3±7.8† | −64.5±7.1† | −43.8±4.9 | −56.7±5.9 | −72.0±4.7 | −37.1±6.4 | −51.3±6.5 | −68.9±5.2 |
| Heart rate, bpm | 0±1 | 2±1 | 1±1 | 2±2 | 0±1 | 0±1 | −1±1 | 0±1 | 0±1 | −1±1 |
| Venous norepinephrine, nmol L−1 | 0.4±0.3 | 6.5±3.0 | 1.4±0.4 | 4.5±1.1 | … | … | … | … | … | … |
Values are means±SE. n=10. PLA indicates placebo; and PROB, probenecid.
*
Significantly different from PLA (P<0.05).
†
Significantly different from leg within same condition (P<0.05).